Shawn R. Campagna
Knoxville, TN 37996-1600
Ph.D., Princeton University (2006)
Research in my group will use organic synthesis, combinatorial methods, and analytical techniques, such as tandem liquid chromatography-mass spectrometry and nuclear magnetic resonance, to answer biologically relevant questions at the molecular level. We have also established collaborations with a number of other researchers, both at UTK and at other universities, and these interactions have enhanced our ability to explore the underlying chemical component of a variety of biological processes. The figure below gives an overview of the research in our laboratory, and more detailed descriptions of the projects will be posted soon.
Dr. Campagna completed his B.S. in Chemistry at North Carolina State University in 2000 and conducted research with Prof. Jonathan S. Lindsey on the chemical synthesis of bacterial chromosomes. He received his Ph.D. from Princeton University in 2006, after working with Prof. Martin F. Semmelhack on a joint project with Profs. Bonnie L. Bassler and Frederick M. Hughson to characterize the chemical properties of an inter-species bacterial signaling molecule, autoinducer-2. Dr. Campagna then performed post-doctoral fellow research with Prof. Joshua D. Rabinowitz at the Lewis-Sigler Institute for Integrative Genomics at Princeton University where he developed mass spectrometric methods for the identification of novel biochemical pathways and natural products from whole cell extracts. He joined the Chemistry Department at UT Knoxville in August 2007.
Van Mooy, B. A. S.; Hmelo, L. R.; Mincer, T. J.; Sofen, L. E.; Campagna, S. R.; May, A. L.; Dyhrman, S. T.; Webb, E. A.; Momper, L., Quorum sensing control of phosphorus acquisition in Trichodesmium colonies. The ISME Journal, 8 September 2011; doi:10.1038/ismej.2011.115
Clasquin, M. F.; Melamud, E.; Singer, A.; Gooding, J. R.; Xu, X.; Dong, A.; Cui, H.; Campagna, S. R.; Savchenko, A.; Yakunin, A. F.; Rabinowitz, J. D.; Caudy, A. A., Riboneogensis in yeast. Cell, 2011, 145(6), 969-980.
Collier, J.J.; Burke, S. J.; Eisenhauer, M. E.; Lu, D.; Sapp, R. C.; Frydman, C. J.; Campagna, S. R., Pancreatic b-cell Death in Response to Pro-inflammatory Cytokines is Distinct from Genuine Apoptosis. PLoS One, 2011, 6(7), e22485.
Gooding, J. R.; May, A. L.; Hilliard, K. R.; Campagna, S. R., Establishing a Quantitative Definition of Quorum Sensing Provides Insight into the Information Content of the Autoinducer Signals in Vibrio harveyi and Escherichia coli. Biochemistry, 2010, 49(27), 5621-5623.
Fairchild J. N.; Horvath, K.; Gooding, J. R.; Campagna, S. R.; Guiochon, G., Two-dimensional liquid chromatography/mass spectrometry/mass spectrometry separation of water-soluble metabolites. J. Chromatography A,2010, 1217(52), 8161-6.
Campagna, S. R.; Gooding, J. R.; May, A. L., Direct Quantitation of the Quorum Sensing Signal, Autoinducer-2, in Clinically Relevant Samples by Liquid Chromatography-Tandem Mass Spectrometry. Analytical Chemistry 2009, 81 (15), 6374-6381.
Semmelhack, M. F.; Campagna, S. R.; Federle, M. J.; Bassler, B. L. "An expeditious synthesis of DPD and boron binding studies," Org. Lett., 2005, 7(4), 569-572.
Miller, S. T.; Xavier, K. B,; Campagna, S. R.; Taga, M. E.; Semmelhack, M. F.; Bassler, B. L.; Hughson, F. M. "Salmonella typhimurium recognizes a chemically distinct form of the bacterial quorum-sensing signal Al-2," Mol. Cell, 2004, 15(5), 677-687.