James Q. Chambers, Analytical Chemistry

455 Buehler Hall, (865) 974-3437; EMAIL:CHAMBERS@NOVELL.CHEM.UTK.EDU

Education   A.B., Princeton University, 1959. Ph.D., University of Kansas, 1964.

Experience:   1964-69 Assistant Professor of Chemistry, Univ. of Colorado. 1969-71 Assistant Professor of Chemistry, Univ. of Tennessee. 1971-79 Associate Professor of Chemistry, Univ. of Tennessee. 1979-present Professor of Chemistry, Univ. of Tennessee.

Research Interests

• Electrochemistry: electrode reactions of multisulfur heterocycles, electrosynthesis, polymer electrochemistry,  electrocatalysis.

• Analytical Chemistry: electroanalytical chemistry of polynucleotides, applications of polymer film modified electrodes.

 

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        "Our research interests are in the general area of Electrochemistry with applications to chemical analysis, biochemistry and synthesis. In the area of bioelectrochemistry, we have followed two strategies for the design of electrochemical sensors for polynucleotides. In the first, conducting organic electrodes are modified to make them reactive with DNA; and in the second, the DNA molecules are modified such that they will exchange electrons with ordinary electrochemical detectors. The ultimate goal is to design sensitive detectors for specific DNA molecules and to understand the associated interfacial chemistry at the molecular level. A variety of applications to biochemistry, forensic science and other fields can be envisioned based on the methodology under development in our laboratory."

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• “Electrochemistry of Covalently Mercurated Uridine Nucleotides. Diffusion and Surface Confined Pathways for the Two-electron Reduction of the Carbon-Mercury Bond, “G. J. Wagner and J. Q. Chambers, Langmuir, 13,  3529-3541 (1997).
  
• "Synthesis and Electrochemistry of Anthraquinone–Oligodeoxynucleotide Conjugates," Neil A. Whittemore^†, Adam N. Mullenix^†, Gopal B. Inamati^‡, Muthiah Manoharan^‡, P. Dan Cook^‡, Al A. Tuinman^†, David C. Baker^†, and James Q. Chambers^†* Bioconjugate Chem. 1999, 10, 261-270.
  
• "Accumulation of Hg(II) by Adsorbed Polyuridylic Acid. Differentiation of Coordinated Hg(II) and Covalently Mercurated Species," Randy F. Johnston, Dori M. Lewis and James Q. Chambers J. Electroanal. Chem. 1999, 466, 2-7.
  
• "Chronoamperometry of Surface-Confined Redox Couples for Irreversible Two-Step and Three-Step Consecutive Reaction Mechanisms," Vilmos Kertesz, James Q. Chambers and Adam N. Mullenix Analyt. Chem. 1999, 71, 3905-3909.
  
• "Chronoamperometry of Surface-Confined Redox Couples. Application to Daunomycin Adsorbed on Hanging Mercury Drop Electrodes," Vilmos Kertesz, James Q. Chambers and Adam N. Mullenix Electrochim. Acta 1999, 45, 1095-1104.
  
• "Electrochemical Detection of Surface Hybridization of Oligodeoxynucleotides Bearing Anthraquinone Tags at Gold Electrodes," Vilmos Kertesz, Neil A. Whittemore^†, Gopal B. Inamati^‡, Muthiah Manoharan^‡, P. Dan Cook^‡, Al A. Tuinman, David C. Baker, and James Q. Chambers^* Electroanalysis, accepted publication.

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